Wolf Y G, Otis S M, Schwend R B, Bernstein E F
Department of Vascular Surgery, Hadassah University Hospital, Jerusalem, Israel.
J Vasc Surg. 1995 Oct;22(4):417-21; discussion 421-3. doi: 10.1016/s0741-5214(95)70009-9.
The purpose of this study was to evaluate the cost-effectiveness of screening for abdominal aortic aneurysms (AAA) during noninvasive lower extremity arterial examination in the vascular laboratory.
Over 30 months we screened 531 patients who underwent lower extremity arterial evaluations in the vascular laboratory. The patients had fasted overnight, and, after the regular noninvasive lower extremity arterial examination, the abdominal aorta was screened with B-mode ultrasonography.
The aorta was adequately visualized in 475 patients (89%). Mean aortic diameter was 19.6 +/- 4.1 mm at the juxtarenal level and 18.8 +/- 7.2 mm in the lower infrarenal aorta. The aortic diameter was larger in men (p < 0.001) and in smokers (p < 0.001). AAA (diameter greater than 3.0 cm) were identified in 32 patients (6.0% of the 531 patients screened), and 15 of the aneurysms were equal to or larger than 4.0 cm. The best predictors for AAA by logistic regression analysis were male sex (p < 0.005), advanced age (greater than 65 years, p < 0.01), and a history of smoking (p < 0.01). The prevalence of AAA was 6.7% (32/475) in the population in whom the aorta was visualized and 15.2% (19/125) in male smokers over 65 years of age. Aneurysms of 4.0 cm or greater were identified in 3.2% of the entire population screened and 8.8% of male smokers over age 65. Limited aortic scanning prolonged the vascular laboratory examination by an average of 5 minutes. Thus detection of one aneurysm required 83 minutes of scanning time for the whole population studied and 36 minutes of scanning of male smokers over age 65, at a cost of $240 to $553 per aneurysm identified.
Screening for AAA during lower extremity arterial evaluation in the vascular laboratory addresses a high-risk population, is cost-effective, and should be considered an appropriate and valuable addition to the examination protocol.
本研究的目的是评估在血管实验室进行无创下肢动脉检查时筛查腹主动脉瘤(AAA)的成本效益。
在30多个月的时间里,我们对531例在血管实验室接受下肢动脉评估的患者进行了筛查。患者过夜禁食,在常规无创下肢动脉检查后,用B型超声对腹主动脉进行筛查。
475例患者(89%)的主动脉得到了充分显影。肾旁水平主动脉平均直径为19.6±4.1mm,肾下主动脉下部为18.8±7.2mm。男性(p<0.001)和吸烟者(p<0.001)的主动脉直径较大。在32例患者(占筛查的531例患者的6.0%)中发现了腹主动脉瘤(直径大于3.0cm),其中15个动脉瘤等于或大于4.0cm。通过逻辑回归分析,腹主动脉瘤的最佳预测因素是男性(p<0.005)、高龄(大于65岁,p<0.01)和吸烟史(p<0.01)。在主动脉得到显影的人群中,腹主动脉瘤的患病率为6.7%(32/475),在65岁以上的男性吸烟者中为15.2%(19/125)。在整个筛查人群中,4.0cm或更大的动脉瘤在3.2%的人群中被发现,在65岁以上的男性吸烟者中为8.8%。有限的主动脉扫描使血管实验室检查平均延长了5分钟。因此,对于整个研究人群,发现一个动脉瘤需要83分钟的扫描时间,对于65岁以上的男性吸烟者则需要36分钟的扫描时间,每发现一个动脉瘤的成本为240美元至553美元。
在血管实验室进行下肢动脉评估时筛查腹主动脉瘤针对的是高危人群,具有成本效益,应被视为检查方案中一项合适且有价值的补充。