Dithmar S, Holz F G, Burk R O, Rohrschneider K, Völcker H E
Universitäts-Augenklinik Heidelberg.
Klin Monbl Augenheilkd. 1995 Jul;207(1):11-6. doi: 10.1055/s-2008-1035342.
Indocyanine-green angiography (ICG) has been shown to be a valuable adjunctive technique to fluorescein angiography including further delineation of choroidal neovascularization in age-related macular degeneration. We report on initial clinical experiences with a newly developed infrared confocal scanning laser ophthalmoscope.
Fundus and fluorescein angiography photographs were obtained in 20 patients with various fundus changes. Confocal laser scanning ICG-angiography using the Heidelberg Retina Angiograph (Heidelberg Engineering GmbH, Germany) was performed after injection of 25 mg ICG. The confocal principle ensures that only light reflected from a defined focal plane is detected by the integrated photomultiplier. Excitation wave-length was 795 nm, and emission was recorded above 810 nm. About 60% of the emission is detected. An additional built-in diode laser (830 nm) allowed fundus visualization prior to dye injection.
ICG angiography using the scanning laser angiograph showed typical findings as previously reported with other systems. The images were characterized by high contrast. In addition, the retinal vessels were readily visualized in the late phase. By means of the confocal mode different layers of the circulation could be visualized.
The findings indicate that the confocal scanning angiograph is a useful alternative tool for ICG angiography and that it offers similar information obtained by other imaging systems. Advantages compared with previous techniques may include high image contrast, visualization of retinal vessels in the late phase, lower amount of light exposure, direct digital image acquisition and easy practical operation.
吲哚菁绿血管造影（ICG）已被证明是荧光素血管造影的一种有价值的辅助技术，包括在年龄相关性黄斑变性中进一步描绘脉络膜新生血管。我们报告了一种新开发的红外共焦扫描激光眼科显微镜的初步临床经验。
对20例有各种眼底病变的患者进行眼底和荧光素血管造影拍照。在注射25mg吲哚菁绿后，使用海德堡视网膜血管造影仪（德国海德堡工程有限公司）进行共焦激光扫描ICG血管造影。共焦原理确保只有从定义的焦平面反射的光被集成光电倍增管检测到。激发波长为795nm，发射光在810nm以上记录。约60%的发射光被检测到。一个额外的内置二极管激光（830nm）允许在注射染料前进行眼底可视化。
使用扫描激光血管造影仪进行的ICG血管造影显示出与其他系统先前报道的典型发现。图像的特点是对比度高。此外，视网膜血管在晚期很容易可视化。通过共焦模式，可以可视化循环的不同层。
这些发现表明，共焦扫描血管造影仪是ICG血管造影的一种有用的替代工具，并且它提供了与其他成像系统获得的类似信息。与先前技术相比，优点可能包括高图像对比度、晚期视网膜血管可视化、较低的光暴露量、直接数字图像采集和易于实际操作。
