Scheider A
Universitäts-Augenklinik München.
Ophthalmologe. 1992 Feb;89(1):27-33.
This report summarizes our first clinical results with indocyanine green angiography using an infrared scanning laser ophthalmoscope (IR-SLO) is equipped with an infrared laser diode of 780 nm and a barrier filter of 830 nm. Angiographies are recorded on videotape and images simultaneously digitized and saved on the disk. For each examination, 25 mg of Indocyanine Green (ICG), dissolved in 5 ml aqueous solvent, is injected into a cubital vein. We came to the following conclusions: First, the detection of subretinal neovascular membranes is certainly improved, especially for ill-defined membranes when the exact demarcation cannot be seen either because of diffuse exudation of fluorescein or because of the pigment epithelium. Second, we were able to demonstrate the lobular structure of the choriocapillary layer and prove that the acute form of posterior multifocal placoid pigment epitheliopathy is derived from a defect in this layer. Third, examination of the meaning sites of retinal and choroidal vessels revealed the additive fluorescence of ICG, which had not previously been known and which is bound to complicate tremendously the analysis of quantitative measurements. Our results prove that this new method is a useful diagnostic procedure for both the clinical routine and research. The different properties of fluorescein and indocyanine green prevent competition of these dyes. ICG represents a true completion.
本报告总结了我们使用配备780纳米红外激光二极管和830纳米屏障滤光片的红外扫描激光检眼镜进行吲哚菁绿血管造影的首批临床结果。血管造影记录在录像带上，图像同时数字化并保存在磁盘上。每次检查时，将25毫克溶解于5毫升水性溶剂中的吲哚菁绿（ICG）注入肘静脉。我们得出了以下结论：第一，视网膜下新生血管膜的检测确实得到了改善，尤其是对于那些因荧光素弥漫性渗出或色素上皮而无法看清确切边界的边界不清的膜。第二，我们能够证明脉络膜毛细血管层的小叶结构，并证明后部多灶性扁平状色素上皮病变的急性形式源自该层的缺陷。第三，对视网膜和脉络膜血管的相应部位进行检查发现了ICG的叠加荧光，这是此前未知的，并且必然会极大地使定量测量分析变得复杂。我们的结果证明，这种新方法对于临床常规和研究都是一种有用的诊断程序。荧光素和吲哚菁绿的不同特性避免了这些染料之间的竞争。ICG代表了一种真正的补充。
