Schneider U, Kreissig I, Inhoffen W
Abt. III, Universitäts-Augenklinik Tübengen.
Klin Monbl Augenheilkd. 1995 Dec;207(6):372-6. doi: 10.1055/s-2008-1035392.
With the development of new imaging technologies indocyanine green (ICG) angiography allows better visualization of choroidal and retinal vasculature and their pathology. Due to its high protein bound ICG leaks very slowly from fenestrated normal and abnormal vessels. With its absorption and emission peak in the near infrared spectrum ICG penetrates hemorrhage to a greater degree than does blue light with shorter wavelength used for fluorescein angiography.
We report the clinical and fluoresceinangiographical findings of three patients with a sudden macular hemorrhage of unknown origin.
In all patients conventional fluoresceinangiography revealed a similar appearance with little characteristic signs early ill-defined hyperfluoroescence and late exudation of dye. ICG angiography clearly demonstrated the underlying pathology as a pulsatile retinal artery macroaneurysm, a choroidal neovascularization secondary to age-related macular degeneration, and a retinal angioma.
ICG videoangiography with its absorption and emission peak in the near infrared light seems to be an additive tool to identify and delineate more precisely fluoresceinangiographically ill-defined hyperfluorescence and exudations in patients with retinal hemorrhage of unknown origin.
随着新型成像技术的发展，吲哚菁绿（ICG）血管造影能够更好地显示脉络膜和视网膜血管系统及其病变情况。由于其与蛋白质高度结合，ICG从有窗孔的正常和异常血管中泄漏非常缓慢。ICG在近红外光谱中有吸收和发射峰，与用于荧光素血管造影的较短波长蓝光相比，它能更大程度地穿透出血部位。
我们报告了3例不明原因的突发性黄斑出血患者的临床及荧光素血管造影检查结果。
在所有患者中，传统荧光素血管造影显示出相似的表现，早期特征性征象较少，为边界不清的高荧光，晚期有染料渗漏。ICG血管造影清楚地显示出潜在病变，分别为搏动性视网膜动脉大动脉瘤、年龄相关性黄斑变性继发的脉络膜新生血管和视网膜血管瘤。
ICG视频血管造影在近红外光中有吸收和发射峰，似乎是一种辅助工具，可更精确地识别和描绘不明原因视网膜出血患者荧光素血管造影中边界不清的高荧光和渗漏情况。
