Kovacheva S, Ribarov S R
Sofia University School of Medicine, Department of Biophysics, Bulgaria.
Lung. 1995;173(4):255-63. doi: 10.1007/BF00181877.
This study was carried out to examine the possibility of initiation of lipid peroxidation in the lung of Wistar albino male rats stressed by immobilization. The effects of vitamin E supplementation were also investigated. We found that immobilization of rats with normal pulmonary content of vitamin E caused lipid peroxidation in the lung. Decrease of the lung content of unsaturated fatty acids and vitamin E was also established. The immobilization-induced changes of all of these parameters were significantly inhibited by vitamin E injection (100 mg/kg body weight) for 7 days. A possible sequence of events leading to the initiation of lipid peroxidation and lung cell membrane damage in rats stressed by immobilization is discussed.
本研究旨在探讨束缚应激的雄性Wistar白化大鼠肺组织中引发脂质过氧化反应的可能性。同时也研究了补充维生素E的效果。我们发现，维生素E肺含量正常的大鼠经束缚后会引发肺组织脂质过氧化反应。不饱和脂肪酸和维生素E的肺含量也有所下降。连续7天注射维生素E（100mg/kg体重）可显著抑制束缚诱导的所有这些参数的变化。本文讨论了束缚应激大鼠中引发脂质过氧化反应和肺细胞膜损伤的可能事件序列。
