Masters C J, Crane D I
Faculty of Science and Technology, Griffith University, Brisbane, Qld, Australia.
Mech Ageing Dev. 1995 May 12;80(2):69-83. doi: 10.1016/0047-6374(94)01563-2.
This article reviews the available data on the role of the peroxisome in the growth, differentiation and degeneration of mammalian tissues. Developmental progressions of peroxisomes are described, along with the influence of inhibitors of peroxisomal enzymes, peroxisome proliferators and morphogenetic agents on the ontogeny of experimental animals. The role of the peroxisome in protecting tissues from damage by oxygen free radicals is also described, as is the changing role of the peroxisome in the ageing animal. Amongst the degenerative diseases which have been associated with free radical damage are cancer, atherosclerosis, muscular dystrophy, rheumatoid arthritis and the senile degeneration of brain function. In all these conditions, the major characteristics of molecular damage have been considered, along with the particular role of the peroxisome in alleviating these effects. Proposals for further research into peroxisomal function during ontogeny and the degenerative changes associated with ageing are developed, and the possibility of palliative treatments discussed.
本文综述了关于过氧化物酶体在哺乳动物组织生长、分化和退化中作用的现有数据。描述了过氧化物酶体的发育进程，以及过氧化物酶体酶抑制剂、过氧化物酶体增殖剂和形态发生剂对实验动物个体发育的影响。还描述了过氧化物酶体在保护组织免受氧自由基损伤中的作用，以及过氧化物酶体在衰老动物中不断变化的作用。与自由基损伤相关的退行性疾病包括癌症、动脉粥样硬化、肌肉萎缩症、类风湿性关节炎和脑功能的老年退化。在所有这些情况下，都考虑了分子损伤的主要特征，以及过氧化物酶体在减轻这些影响中的特殊作用。提出了关于进一步研究个体发育过程中过氧化物酶体功能以及与衰老相关的退行性变化的建议，并讨论了姑息治疗的可能性。
