Pisano F, Miscio G, Mazzuero G, Lanfranchi P, Colombo R, Pinelli P
Neurophysiological Unit, Salvatore Maugeri Foundation, Medical Centre of Rehabilitation, Veruno (NO), Italy.
Muscle Nerve. 1995 Nov;18(11):1225-31. doi: 10.1002/mus.880181103.
Autoregressive spectral analysis of heart rate variability (HRV) was performed in 29 patients with amyotrophic lateral sclerosis (ALS) and 33 age-matched healthy subjects to evaluate the involvement of the autonomic nervous system. HRV analysis provides a means to recognize low (LF) and high (HF) frequency components, respectively mediated by sympathetic and parasympathetic heart control. An increase in the mean heart rate at rest (P < 0.001), a decrease in standard deviation of R-R interval as well as in PNN50 (P < 0.001), and an increase in the LF/HF component ratio (P < 0.01) were found in the ALS patients, indicating a vagal-sympathetic imbalance. These alterations were not related to the clinical features and to the duration of the disease. Our results suggest a subclinical involvement of the autonomic nervous system in ALS, particularly affecting parasympathetic cardiovascular control.
对29例肌萎缩侧索硬化症（ALS）患者和33例年龄匹配的健康受试者进行了心率变异性（HRV）的自回归谱分析，以评估自主神经系统的受累情况。HRV分析提供了一种识别分别由交感神经和副交感神经心脏控制介导的低频（LF）和高频（HF）成分的方法。在ALS患者中发现静息时平均心率增加（P<0.001），R-R间期标准差以及PNN50降低（P<0.001），LF/HF成分比值增加（P<0.01），表明迷走神经-交感神经失衡。这些改变与疾病的临床特征和病程无关。我们的结果表明自主神经系统在ALS中存在亚临床受累，尤其影响副交感神经对心血管的控制。
