辅酶Q10和维生素E对人低密度脂蛋白亚组分过氧化作用的影响
The roles of coenzyme Q10 and vitamin E on the peroxidation of human low density lipoprotein subfractions.
作者信息
Alleva R, Tomasetti M, Battino M, Curatola G, Littarru G P, Folkers K
机构信息
Institute of Biochemistry, Faculty of Medicine, University of Ancona, Italy.
出版信息
Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9388-91. doi: 10.1073/pnas.92.20.9388.
Abstract
The aim of our study was to investigate the relationships between the levels of coenzyme Q10 (CoQ10) and vitamin E and the levels of hydroperoxide in three subfractions of low density lipoproteins (LDL) that were isolated from healthy donors. LDL3, the densest of the three subfractions, has shown statistically significant lower levels of CoQ10 and vitamin E, which were associated with higher hydroperoxide levels when compared with the lighter counterparts. After CoQ10 supplementation, all three LDL subfractions had significantly increased CoQ10 levels. In particular, LDL3 showed the highest CoQ10 increase when compared with LDL1 and LDL2 and was associated with a significant decrease in hydroperoxide level. These results support the hypothesis that the CoQ10 endowment in subfractions of LDL affects their oxidizability, and they have important implications for the treatment of disease.
摘要
我们研究的目的是调查从健康供体中分离出的低密度脂蛋白（LDL）三个亚组分中辅酶Q10（CoQ10）和维生素E的水平与过氧化氢水平之间的关系。LDL3是这三个亚组分中密度最大的，与较轻的对应物相比，其CoQ10和维生素E水平在统计学上显著较低，而过氧化氢水平较高。补充CoQ10后，所有三个LDL亚组分的CoQ10水平均显著升高。特别是，与LDL1和LDL2相比，LDL3的CoQ10增加最多，并且与过氧化氢水平的显著降低相关。这些结果支持了以下假设：LDL亚组分中的CoQ10含量会影响其氧化能力，并且对疾病治疗具有重要意义。
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