Vik-Mo H
Scand J Haematol. 1977 Jul;19(1):68-74. doi: 10.1111/j.1600-0609.1977.tb02720.x.
The effect of an acute myocardial ischaemia on circulating platelet aggregates (CPA) in the coronary sinus and aorta was studied in open chest dogs. Even before induction of myocardial ischaemia significantly more CPA were found in the coronary sinus than in the aorta. Acute myocardial ischaemia produced by a non-thrombotic coronary artery occlusion increased CPA in coronary sinus, but not in aorta. Administration of acetylsalicylic acid (ASA) reduced the extent of the myocardial ischaemia as evidenced by reduced ST-segment elevations in epicardial ECG. Before induction of myocardial ischaemia, ASA significantly reduced CPA in coronary sinus, but no significant effect was observed during myocardial ischaemia. In the aorta no effect of ASA on CPA was found.
在开胸犬身上研究了急性心肌缺血对冠状窦和主动脉中循环血小板聚集体（CPA）的影响。甚至在诱导心肌缺血之前，冠状窦中发现的CPA就明显多于主动脉。非血栓性冠状动脉闭塞所致的急性心肌缺血会增加冠状窦中的CPA，但不会增加主动脉中的CPA。乙酰水杨酸（ASA）给药可减轻心肌缺血程度，表现为心外膜心电图中ST段抬高降低。在诱导心肌缺血之前，ASA可显著降低冠状窦中的CPA，但在心肌缺血期间未观察到显著影响。在主动脉中，未发现ASA对CPA有影响。
