Takiguchi M, Takaya T
Department of Anesthesiology, Tokai University School of Medicine, Kanagawa, Japan.
Tokai J Exp Clin Med. 1994 Dec;19(3-6):131-7.
A significant reduction was noticed in the amount of vecuronium needed to maintain steady neuromuscular blockade at 20% twitch height (T1) in patients given nicardipine intraoperatively. Bolus injection of either nicardipine or diltiazem during constant infusion of vecuronium produced transient depression of T1 and the train-of-four ratio (TOFR). Reversal of neuromuscular blockade with a choline esterase inhibitor (neo-stigmine) was not retarded by previous administration of Ca-channel blockers but concurrent administration of anticholine-esterase agent and Ca-channel blockers caused a delay in recovery from motor blockade. Monitoring of neuromuscular junction activity is strongly recommended whenever a large cumulative dose of Ca-channel blockers is used.
术中接受尼卡地平治疗的患者，维持20%颤搐高度（T1）稳定神经肌肉阻滞所需的维库溴铵量显著减少。在持续输注维库溴铵期间，静脉推注尼卡地平或地尔硫䓬会导致T1和四个成串刺激比率（TOFR）短暂降低。胆碱酯酶抑制剂（新斯的明）逆转神经肌肉阻滞并不受先前使用钙通道阻滞剂的影响，但抗胆碱酯酶药物与钙通道阻滞剂同时使用会导致运动阻滞恢复延迟。当使用大剂量累积钙通道阻滞剂时，强烈建议监测神经肌肉接头活动。
