Pou A M, Rimell F L, Jordan J A, Shoemaker D L, Johnson J T, Barua P, Post J C, Ehrlich G D
Department of Otolaryngology, Children's Hospital of Pittsburgh, Pennsylvania, USA.
Ann Otol Rhinol Laryngol. 1995 Oct;104(10 Pt 1):758-62. doi: 10.1177/000348949510401002.
Pathologic material and the records of 29 patients with laryngeal papillomatosis were reviewed. The relationship between the type of human papillomavirus (HPV) and the presence of viral coinfections was correlated with clinical outcome. Using polymerase chain reaction, paraffin-embedded specimens were analyzed for the presence of HPV, Epstein-Barr virus (EBV), cytomegalovirus (CMV), and herpes simplex virus (HSV). The HPV type could be identified in 24 patients' specimens. Twenty-one patients were infected with HPV type 6. The other 3 were infected with HPV type 11 or 16. Three patients developed squamous cell carcinoma, of whom 2 had HPV type 11 or 16. We found HSV, EBV, and CMV in 50%, 12.5%, and 0% of specimens, respectively. An aggressive clinical course was observed in 17 patients. Evidence of coinfection with other viruses was identified in 11 (65%) of these patients. In contrast, a benign clinical course was observed in 7 patients, of whom 2 (29%) had viral coinfections. We conclude that the HPV type and the presence of viral coinfections may be predictive of an aggressive clinical course.
回顾了29例喉乳头状瘤病患者的病理材料和记录。人乳头瘤病毒（HPV）类型与病毒合并感染的存在与临床结果相关。使用聚合酶链反应，对石蜡包埋标本进行HPV、爱泼斯坦-巴尔病毒（EBV）、巨细胞病毒（CMV）和单纯疱疹病毒（HSV）检测。在24例患者的标本中可鉴定出HPV类型。21例患者感染了6型HPV。另外3例感染了11型或16型HPV。3例患者发生了鳞状细胞癌，其中2例感染了11型或16型HPV。我们分别在50%、12.5%和0%的标本中发现了HSV、EBV和CMV。17例患者观察到侵袭性临床病程。在这些患者中的11例（65%）发现了与其他病毒合并感染的证据。相比之下，7例患者观察到良性临床病程，其中2例（29%）有病毒合并感染。我们得出结论，HPV类型和病毒合并感染的存在可能预示着侵袭性临床病程。
