Smyth A R, Smyth R L, Tong C Y, Hart C A, Heaf D P
Respiratory Unit, Royal Liverpool Children's Hospital, Alder Hey.
Arch Dis Child. 1995 Aug;73(2):117-20. doi: 10.1136/adc.73.2.117.
One hundred and eight patients with cystic fibrosis were investigated over one year to determine whether an association existed between rhinovirus or other respiratory virus infection and clinical status. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), Shwachman score, Chrispin-Norman chest radiograph score, and percentage weight for height were recorded at the beginning and end of the study; days of intravenous antibiotics were noted. Nasopharyngeal aspirates were taken for viral studies during respiratory exacerbations. Serum was collected at enrollment and 2-6 weeks after each respiratory exacerbation. One hundred and fifty seven exacerbations occurred in 76 patients. Respiratory virus infection was detected in 44 exacerbations and rhinovirus was present in 16% (25/157) of exacerbations. Patients with one or more respiratory virus infections were compared with those who had none. When all respiratory virus infections were considered, patients had a significantly greater deterioration in Shwachman score and received significantly more days of intravenous antibiotics. When rhinovirus was considered separately, patients received significantly more days of intravenous antibiotics, but showed no deterioration in clinical status. However, patients infected with another respiratory virus had a significant decline in FEV1, with trends towards significance for decline in FVC and Shwachman score.
在一年的时间里，对108名囊性纤维化患者进行了调查，以确定鼻病毒或其他呼吸道病毒感染与临床状况之间是否存在关联。在研究开始和结束时记录一秒用力呼气量（FEV1）、用力肺活量（FVC）、舒瓦克曼评分、克里斯平 - 诺曼胸部X光评分以及身高体重百分比；记录静脉使用抗生素的天数。在呼吸道病情加重期间采集鼻咽抽吸物进行病毒学研究。在入组时以及每次呼吸道病情加重后2 - 6周采集血清。76名患者共发生了157次病情加重。在44次病情加重中检测到呼吸道病毒感染，鼻病毒在16%（25/157）的病情加重中出现。将有一次或多次呼吸道病毒感染的患者与未感染的患者进行比较。当考虑所有呼吸道病毒感染时，患者的舒瓦克曼评分恶化程度显著更高，接受静脉使用抗生素的天数也显著更多。当单独考虑鼻病毒时，患者接受静脉使用抗生素的天数显著更多，但临床状况没有恶化。然而，感染其他呼吸道病毒的患者FEV1显著下降，FVC和舒瓦克曼评分有下降的趋势但未达到显著水平。
