Knable M B, Weinberger D R
National Institute of Mental Health, National Institutes of Health, Clinical Brain Disorders Branch, Washington, D.C., USA.
Eur Arch Psychiatry Clin Neurosci. 1995;245(4-5):224-30. doi: 10.1007/BF02191801.
Nearly a century after the seminal contributions of Emil Kraepelin, the search for neuropathologic correlates of schizophrenic psychoses continues. A multitude of neuroanatomic and neurochemical findings has emerged in recent years, but many of these findings are not replicated or are difficult to interpret in light of methodologic problems. In this review replicated neuropathologic and neuroimaging studies are discussed. The hypothesis that emerges from these studies is that schizophrenia is a developmental abnormality affecting the connectivity of the prefrontal and medial temporal cortices.
在埃米尔·克雷佩林做出开创性贡献近一个世纪后，对精神分裂症性精神病神经病理学相关因素的探索仍在继续。近年来出现了大量神经解剖学和神经化学方面的研究结果，但鉴于方法学问题，其中许多结果无法重复或难以解释。在这篇综述中，我们将讨论可重复的神经病理学和神经影像学研究。从这些研究中得出的假说是，精神分裂症是一种影响前额叶和颞叶内侧皮质连接性的发育异常。
