Masson M, Rolli V, Dantzer F, Trucco C, Schreiber V, Fribourg S, Molinete M, Ruf A, Miranda E A, Niedergang C
Ecole Supérieure de Biotechnologie de Strasbourg, UPR 9003 du CNRS, Illkirch, France.
Biochimie. 1995;77(6):456-61. doi: 10.1016/0300-9084(96)88160-0.
Dissection of the human poly(ADP-ribose) polymerase (PARP) molecule in terms of its structure-function relationship has proved to be an essential step towards understanding the biological role of poly(ADP-ribosylation) as a cellular response to DNA damage in eukaryotes. Current approaches aimed at elucidating the implication of this multifunctional enzyme in the maintenance of the genomic integrity will be presented.
从结构-功能关系的角度剖析人类聚（ADP-核糖）聚合酶（PARP）分子，已被证明是理解聚（ADP-核糖基化）作为真核生物细胞对DNA损伤的一种反应的生物学作用的关键一步。本文将介绍旨在阐明这种多功能酶在维持基因组完整性中的作用的当前方法。
