van Furth A M, Seijmonsbergen E M, Langermans J A, Groeneveld P H, de Bel C E, van Furth R
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
Clin Infect Dis. 1995 Jul;21(1):220-2. doi: 10.1093/clinids/21.1.220.
Since interleukin-10 (IL-10) controls the production of tumor necrosis factor alpha (TNF-alpha) and this latter cytokine has a deleterious effect on neuronal cells, we determined the levels of both cytokines in cerebrospinal fluid (CSF) from children with bacterial meningitis. High levels of IL-10 (1,164 pg/mL) and TNF-alpha (3,158 pg/mL) were detected in CSF from 10 children with meningitis, but these cytokines were not detectable in CSF from 12 controls. In vitro neutralization of IL-10 demonstrated that endogenously formed IL-10 is important for limiting the production of TNF-alpha by leukocytes. We assume that IL-10 in CSF will decrease the inflammatory reaction associated with meningitis and will result in the development of fewer sequelae because of its inhibitory effect on the production of TNF-alpha.
由于白细胞介素-10（IL-10）可控制肿瘤坏死因子α（TNF-α）的产生，且后一种细胞因子对神经元细胞具有有害作用，因此我们测定了细菌性脑膜炎患儿脑脊液（CSF）中这两种细胞因子的水平。在10例脑膜炎患儿的脑脊液中检测到高水平的IL-10（1164 pg/mL）和TNF-α（3158 pg/mL），但在12例对照者的脑脊液中未检测到这些细胞因子。IL-10的体外中和实验表明，内源性产生的IL-10对于限制白细胞产生TNF-α很重要。我们推测，脑脊液中的IL-10将减少与脑膜炎相关的炎症反应，并因其对TNF-α产生的抑制作用而导致后遗症的发生减少。
