Paquet K J, Oberhammer E
Endoscopy. 1978 Feb;10(1):7-12. doi: 10.1055/s-0028-1098252.
From 1.1.1969 up to 1.11.1977, 640 patients with hemorrhage from gastro-oesopheal varices were managed by sclerotherapy of the oesophageal wall. In 90% this method succeeded in stopping hemorrhage or preventing a new bleeding during the next four months. Only 43 patients of the total number were treated because of impending hemorrhage under precise indications. After two or three sessions of sclerotherapy the interval of control can be extended up to one years without new danger of hemorrhage. Overall mortality was 14.5%; main causes of death were liver coma, uncontrollable hemorrhage, mediastinitis and pyothorax.--If liver function improves, a porto-systemic-shunt is performed whenever possible.--416 = 65% of the patients are still alive; 50% longer than one year up to eight years. Thus sclerotherapy seems to be the method of choice in uncurable massive hemorrhage from varicosities from the oesophagus. It is indicated in patients with decompensated liver function, and whenever a shunt procedure is anatomically or clinically impossible or not advisable, too.
从1969年1月1日至1977年11月1日，对640例食管静脉曲张出血患者进行了食管壁硬化治疗。90%的患者通过该方法成功止血或在接下来的四个月内防止再次出血。在明确指征下，仅对总数中的43例患者因即将发生的出血进行了治疗。经过两到三次硬化治疗后，复查间隔可延长至一年而无再次出血的新风险。总死亡率为14.5%；主要死亡原因是肝昏迷、无法控制的出血、纵隔炎和脓胸。——如果肝功能改善，尽可能进行门体分流术。——416例（占65%）患者仍然存活；50%的患者存活时间超过一年，最长达八年。因此，硬化治疗似乎是治疗无法治愈的食管静脉曲张大量出血的首选方法。它适用于肝功能失代偿的患者，以及在解剖学或临床上无法进行或不建议进行分流手术的情况。
