Botsch H, Oepen G, Deuschl G, Wolff G
St. Josefskrankenhaus und Psychiatrische Universitätsklinik, Freiburg.
Rofo. 1987 Dec;147(6):666-8. doi: 10.1055/s-2008-1048720.
Huntington's chorea is an autosomal dominant inherited disease with a chronic course and atrophy of the corpus striatum. PET examination shows reduced glucose metabolism in the caudate nucleus. We examined seven patients with Huntington's chorea by SPECT, using 99mTc-HMPAO. All patients had cortical defects of varying severity. In addition, five patients showed increased uptake in the region of the caudate nucleus. The specific tracer uptake due to the metabolic processes in the region of the caudate nucleus in Huntington's chorea is discussed.
亨廷顿舞蹈病是一种常染色体显性遗传病，病程慢性，伴有纹状体萎缩。正电子发射断层扫描（PET）检查显示尾状核葡萄糖代谢降低。我们使用99m锝-六甲基丙烯胺肟（99mTc-HMPAO）单光子发射计算机断层扫描（SPECT）对7例亨廷顿舞蹈病患者进行了检查。所有患者均有不同程度的皮质缺损。此外，5例患者尾状核区域摄取增加。本文讨论了亨廷顿舞蹈病中尾状核区域代谢过程引起的特异性示踪剂摄取情况。
