Zimmerman A L
Department of Physiology, Brown University, Providence, Rhode Island 02912, USA.
Curr Opin Neurobiol. 1995 Jun;5(3):296-303. doi: 10.1016/0959-4388(95)80041-7.
Recent studies have revealed that cyclic nucleotide gated channels have a variety of forms and functions. These channels are now thought to be heteromultimers of at least two kinds of subunits and to undergo functional modulation. Ion permeation involves at least two ion-binding sites, and recent work on the alpha subunit suggests that many structural regions are involved in the control of channel gating. The continued use of both molecular and physiological approaches promises to further our understanding of how these channels work and how they are involved in cellular function.
最近的研究表明，环核苷酸门控通道具有多种形式和功能。现在认为这些通道是至少两种亚基的异源多聚体，并会经历功能调节。离子通透涉及至少两个离子结合位点，最近对α亚基的研究表明，许多结构区域参与通道门控的控制。继续使用分子和生理学方法有望进一步加深我们对这些通道如何工作以及它们如何参与细胞功能的理解。
