Murphy S, Fitzgerald M, Mulcahy R, Keane C, Coakley D, Scott T
Mercers Institute for Research on Ageing, St. James's Hospital, Dublin, Ireland.
Gerontology. 1997;43(5):277-82. doi: 10.1159/000213863.
A total of 40 strains of Moraxella catarrhalis, isolated from the sputum of elderly persons with respiratory tract infections and from nasopharyngeal swabs from healthy elderly, were examined for haemagglutination of human red blood cells and resistance to bactericidal activity in normal human serum (NHS). 15 of 20 strains isolated from the infected elderly and 3 of 20 strains isolated from the healthy elderly showed haemagglutinating properties (p < 0.001). Similarly, 13 of 20 strains from the infected group and 2 of 20 strains from the healthy group were found to be resistant to the bactericidal activity of NHS (p < 0.001). Strains of M. catarrhalis which were associated with respiratory tract infections in the elderly, in contrast to strains colonizing the healthy elderly, were found to be predominantly haemagglutinating for human red blood cells and resistant to complement killing in NHS.
从患有呼吸道感染的老年人痰液以及健康老年人的鼻咽拭子中分离出40株卡他莫拉菌，检测其对人红细胞的血凝作用以及对正常人血清（NHS）杀菌活性的抗性。从感染老年人中分离出的20株菌株中有15株，从健康老年人中分离出的20株菌株中有3株表现出血凝特性（p<0.001）。同样，感染组20株菌株中有13株，健康组20株菌株中有2株对NHS的杀菌活性具有抗性（p<0.001）。与定殖于健康老年人的菌株相比，在老年人呼吸道感染中发现的卡他莫拉菌菌株主要对人红细胞具有血凝作用，并且对NHS中的补体杀伤具有抗性。
