Kolarzyk E
Department of Occupational Medicine and Occupational Diseases Collegium Medicum, Jagiellonian University, Cracow, Poland.
Int J Occup Med Environ Health. 1995;8(2):89-101.
The contribution of the central and peripheral nervous system to the regulation of breathing in acute carbon monoxide poisoning was evaluated through the analysis of respiratory pattern parameters, mainly the values of tidal volume to the inspiratory flow (VT/T(in)--driving component), and the relation of inspiratory time to the total cycle time (T(in)/T(tot)--timing component). In the examination performed as soon as possible after poisoning, an increase in the value of the VT/T(in) parameter and a diminishing of T(in)/T(tot) value were noted. Lightly poisoned subjects showed higher dynamics of changes in the regulation of breathing than the medium and severely poisoned patients. Both respiratory pattern components, measured after treatment, were in the lightly poisoned group comparable to the healthy subjects, whereas in the medium and severely poisoned group the value of VT/T(in) was elevated, and the value of T(in)/T(tot) was lessened in comparison to the control counterpart. Both respiratory pattern components significantly correlated to the blood lactace level, and to the degree of poisoning estimated in a complex way.
通过分析呼吸模式参数，主要是潮气量与吸气流量的比值（VT/T(in)——驱动成分）以及吸气时间与总周期时间的关系（T(in)/T(tot)——定时成分），评估中枢和外周神经系统在急性一氧化碳中毒时对呼吸调节的作用。在中毒后尽快进行的检查中，发现VT/T(in)参数值增加，T(in)/T(tot)值降低。轻度中毒患者在呼吸调节变化方面比中度和重度中毒患者表现出更高的动态变化。治疗后测量的两个呼吸模式成分，在轻度中毒组与健康受试者相当，而在中度和重度中毒组中，与对照组相比，VT/T(in)值升高，T(in)/T(tot)值降低。两个呼吸模式成分均与血乳酸水平以及综合评估的中毒程度显著相关。
