Wilson P W, Garrison R J, Kannel W B, McGee D L, Castelli W P
Framingham Study, National Heart, Lung, Blood Institute, MA 01701.
Arch Intern Med. 1989 May;149(5):1169-72.
Reported coffee consumption during 1954 to 1958 and 1971 to 1973 was used to test for association with cardiovascular disease (CVD) incidence and lipid values in the Framingham cohort. Multivariate analysis was employed, regressing CVD on age, systolic pressure, cigarette use, body mass index, total cholesterol, and coffee intake. In pooled analyses (2648 men with 549 CVD cases and 3566 women with 462 CVD cases) coffee intake was not associated with CVD incidence in either smokers or nonsmokers, irrespective of sex. Similarly, multivariate analyses for individuals with existing cardiovascular disease showed no association between coffee intake and subsequent cardiovascular disease. In men significant negative associations between coffee and total cholesterol, and very-low-density lipoprotein cholesterol were seen, whereas in women positive associations with low-density lipoprotein cholesterol were observed. Although inconsistent effects on the lipid profile were seen, no increase in primary or secondary CVD was seen with coffee drinking.
1954年至1958年以及1971年至1973年期间报告的咖啡摄入量，被用于检验与弗雷明汉队列中心血管疾病（CVD）发病率和血脂值之间的关联。采用多变量分析，将心血管疾病作为因变量，以年龄、收缩压、吸烟情况、体重指数、总胆固醇和咖啡摄入量作为自变量进行回归分析。在汇总分析中（2648名男性中有549例心血管疾病病例，3566名女性中有462例心血管疾病病例），无论吸烟与否，咖啡摄入量与心血管疾病发病率均无关联，且与性别无关。同样，对患有心血管疾病的个体进行的多变量分析显示，咖啡摄入量与随后的心血管疾病之间没有关联。在男性中，咖啡与总胆固醇以及极低密度脂蛋白胆固醇之间存在显著的负相关，而在女性中，观察到咖啡与低密度脂蛋白胆固醇之间存在正相关。尽管对血脂谱的影响不一致，但喝咖啡并未导致原发性或继发性心血管疾病增加。
