Jagetia G C, Adiga S K
Department of Radiobiology, Kasturba Medical College, Manipal, India.
Cancer Lett. 1995 Sep 25;96(2):195-200. doi: 10.1016/0304-3835(95)03929-q.
The clastogenic effect of various concentrations of taxol, namely 0, 10, 25, 50, 100, 250 and 500 nM was evaluated in V79 cells grown in vitro. Treatment of V79 cells with different concentrations of taxol reduced the survival in a concentration dependent manner. However, the frequency of micronuclei increased in a concentration dependent manner and the dose response was linear quadratic. Similarly, lactate dehydrogenase also increased with the increase in taxol concentration. The micronuclei and lactate dehydrogenase showed an inverse relationship with the cell survival.
在体外培养的V79细胞中评估了不同浓度（即0、10、25、50、100、250和500 nM）紫杉醇的致断裂效应。用不同浓度的紫杉醇处理V79细胞会以浓度依赖性方式降低细胞存活率。然而，微核频率以浓度依赖性方式增加，且剂量反应呈线性二次关系。同样，乳酸脱氢酶也随着紫杉醇浓度的增加而增加。微核和乳酸脱氢酶与细胞存活率呈负相关。
