Sharma S S, Bhargava N, Mathur S C
Department of Medicine, SMS Medical College & Hospital, Jaipur, India.
Dig Dis Sci. 1995 Nov;40(11):2446-9. doi: 10.1007/BF02063252.
Erythromycin, a motilin receptor agonist has been shown to have prokinetic effects on the upper gastrointestinal tract and gallbladder. Colonic effects of the drug are controversial, and it is debated whether human colon contains motilin receptors. In this study we evaluated the effects of erythromycin on colonic transit and stool frequency in 11 patients with idiopathic constipation over a 1-month period in an open study. The dose used was 1 g/day for two weeks followed by 500 mg/day for another two weeks. The mean (SE) total and segmental colonic transit was measured before and seven days after therapy in seven of these patients. A daily record of stool frequency was maintained in all 11 patients. Erythromycin shortened the total colonic transit from 86.2 (14.6) to 44.8 (8.99) hr (P < 0.01); however, segmental transit studies revealed a significant effect (P < 0.01) only in the right colon and rectosigmoid region. No significant side effects were observed with short-term therapy. These preliminary results suggest that erythromycin is of therapeutic value in patients with idiopathic constipation.
红霉素作为一种胃动素受体激动剂，已被证明对上消化道和胆囊有促动力作用。该药对结肠的作用存在争议，关于人类结肠是否含有胃动素受体也存在争论。在本项开放性研究中，我们评估了红霉素对11例特发性便秘患者结肠传输和排便频率的影响，为期1个月。使用的剂量为1克/天，持续两周，随后500毫克/天，再持续两周。其中7例患者在治疗前和治疗7天后测量了平均（标准误）全结肠和节段性结肠传输时间。所有11例患者均记录每日排便频率。红霉素使全结肠传输时间从86.2（14.6）小时缩短至44.8（8.99）小时（P < 0.01）；然而，节段性传输研究显示仅在右结肠和直肠乙状结肠区域有显著作用（P < 0.01）。短期治疗未观察到明显副作用。这些初步结果表明，红霉素对特发性便秘患者具有治疗价值。
