孕酮可诱导人类精子趋化性。
Progesterone induces human sperm chemotaxis.
作者信息
Villanueva-Díaz C, Arias-Martínez J, Bermejo-Martínez L, Vadillo-Ortega F
机构信息
Departamento de Fisiología de la Reproducción, Instituto Nacional de Perinatología, Mexico, D.F., Mexico.
出版信息
Fertil Steril. 1995 Dec;64(6):1183-8. doi: 10.1016/s0015-0282(16)57982-5.
OBJECTIVE
To characterize the molecular nature of the chemotactic signal for sperm contained in human follicular fluid (FF).
DESIGN
Follicular fluid was fractionated and several procedures were followed to the physicochemical initial characterization of sperm chemotactic compound(s).
MAIN OUTCOME MEASURE
Relative chemotactic activity of each fraction was measured in a double chamber device.
RESULTS
Sperm chemotaxis was found to be associated with a lipid-like molecule extracted from FF. Several steroids were assayed individually and only P showed sperm chemotactic properties in dose-response curves.
CONCLUSIONS
In this paper we present experimental evidence to support the hypothesis that P, the main steroid component of FF, is a mediator of sperm chemoattraction in human beings.
目的
鉴定人卵泡液（FF）中所含精子趋化信号的分子性质。
设计
对卵泡液进行分级分离，并采用多种方法对精子趋化化合物进行物理化学初步鉴定。
主要观察指标
在双室装置中测量各分级分离物的相对趋化活性。
结果
发现精子趋化与从卵泡液中提取的一种类脂分子有关。分别检测了几种甾体，只有孕酮在剂量反应曲线中表现出精子趋化特性。
结论
在本文中，我们提供了实验证据来支持以下假设，即孕酮作为卵泡液的主要甾体成分，是人类精子化学吸引的介质。
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