Sheu C W, Rodriguez I, Dobras S N, Lee J K
Genetic Toxicology Branch, Food and Drug Administration, Washington, DC 20204, USA.
Food Chem Toxicol. 1995 Oct;33(10):883-5. doi: 10.1016/0278-6915(95)00050-c.
Okadaic acid is produced by several types of dinoflagellates (marine plankton) and has been implicated as a causative agent of diarrhoetic shellfish poisoning. Okadaic acid, a known tumour promoter in vivo, has been shown to promote morphological transformation of carcinogen-initiated BALB/3T3 cells. This study shows that okadaic acid is capable of inducing morphological transformation of BALB/3T3 cells in the absence of an initiator.
冈田酸由几种甲藻（海洋浮游生物）产生，被认为是腹泻性贝类中毒的病原体。冈田酸是一种已知的体内肿瘤促进剂，已被证明能促进致癌物引发的BALB/3T3细胞的形态转化。本研究表明，冈田酸在没有引发剂的情况下能够诱导BALB/3T3细胞的形态转化。
