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1
Identification of a mutation in the pst-phoU operon that reduces pathogenicity of an Escherichia coli strain causing septicemia in pigs.鉴定pst-phoU操纵子中的一种突变，该突变可降低引起猪败血症的大肠杆菌菌株的致病性。
Infect Immun. 1995 Dec;63(12):4924-7. doi: 10.1128/iai.63.12.4924-4927.1995.
2
Pathogenicity of an Escherichia coli O115:K"V165" mutant negative for F165(1) fimbriae in septicemia of gnotobiotic pigs.无菌猪败血症中F165(1)菌毛阴性的大肠杆菌O115:K"V165"突变株的致病性
Infect Immun. 1993 Mar;61(3):836-43. doi: 10.1128/iai.61.3.836-843.1993.
3
PhoU enhances the ability of extraintestinal pathogenic Escherichia coli strain CFT073 to colonize the murine urinary tract.PhoU增强了肠道外致病性大肠杆菌菌株CFT073定殖于小鼠泌尿道的能力。
Microbiology (Reading). 2006 Jan;152(Pt 1):153-160. doi: 10.1099/mic.0.28281-0.
4
Presence and characterization of extraintestinal pathogenic Escherichia coli virulence genes in F165-positive E. coli strains isolated from diseased calves and pigs.从患病犊牛和猪分离出的F165阳性大肠杆菌菌株中肠外致病性大肠杆菌毒力基因的存在及特征分析
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5
Contribution of the pst-phoU operon to cell adherence by atypical enteropathogenic Escherichia coli and virulence of Citrobacter rodentium.pst-phoU操纵子对非典型肠致病性大肠杆菌细胞黏附及鼠柠檬酸杆菌毒力的作用。
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6
Septicemia-inducing Escherichia coli O115:K"V165"F165(1) resists killing by porcine polymorphonuclear leukocytes in vitro: role of F165(1) fimbriae and K"V165" O-antigen capsule.诱导败血症的大肠杆菌O115:K“V165”F165(1)在体外可抵抗猪多形核白细胞的杀伤作用：F165(1)菌毛和K“V165”O抗原荚膜的作用
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7
Molecular characterization of extraintestinal pathogenic Escherichia coli (ExPEC) pathogenicity islands in F165-positive E. coli strain from a diseased animal.来自患病动物的F165阳性大肠杆菌菌株中肠外致病性大肠杆菌（ExPEC）致病岛的分子特征分析
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8
Use of the rep technique for allele replacement to construct mutants with deletions of the pstSCAB-phoU operon: evidence of a new role for the PhoU protein in the phosphate regulon.使用重复技术进行等位基因替换以构建缺失pstSCAB-phoU操纵子的突变体：PhoU蛋白在磷酸盐调节子中的新作用证据。
J Bacteriol. 1993 Nov;175(21):6797-809. doi: 10.1128/jb.175.21.6797-6809.1993.
9
Mutations in the f165(1)A and f165(1)E fimbrial genes and regulation of their expression in an Escherichia coli strain causing septicemia in pigs.引起猪败血症的大肠杆菌菌株中f165(1)A和f165(1)E菌毛基因的突变及其表达调控
Microb Pathog. 1997 Apr;22(4):247-52. doi: 10.1006/mpat.1996.0111.
10
Characterization of a polysaccharide capsular antigen of septicemic Escherichia coli O115:K "V165" :F165 and evaluation of its role in pathogenicity.败血性大肠杆菌O115:K“V165”:F165的一种多糖荚膜抗原的特性及其致病性作用评估
Infect Immun. 1992 Dec;60(12):5048-56. doi: 10.1128/iai.60.12.5048-5056.1992.

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PhoB activates Escherichia coli O157:H7 virulence factors in response to inorganic phosphate limitation.PhoB在无机磷酸盐限制的情况下激活大肠杆菌O157:H7的毒力因子。
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10
Bacterial symbioses of the medicinal leech Hirudo verbana.医用水蛭 Hirudo verbana 的细菌共生体。
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本文引用的文献

1
Use of the rep technique for allele replacement to construct mutants with deletions of the pstSCAB-phoU operon: evidence of a new role for the PhoU protein in the phosphate regulon.使用重复技术进行等位基因替换以构建缺失pstSCAB-phoU操纵子的突变体：PhoU蛋白在磷酸盐调节子中的新作用证据。
J Bacteriol. 1993 Nov;175(21):6797-809. doi: 10.1128/jb.175.21.6797-6809.1993.
2
Hyper-invasive mutants define a novel Pho-regulated invasion pathway in Escherichia coli.超侵袭性突变体定义了大肠杆菌中一种新的 Pho 调控的侵袭途径。
Mol Microbiol. 1993 Dec;10(5):1125-37. doi: 10.1111/j.1365-2958.1993.tb00982.x.
3
Analysis of genes coding for the major and minor fimbrial subunits of the Prs-like fimbriae F165(1) of porcine septicemic Escherichia coli strain 4787.猪败血性大肠杆菌菌株4787的类Prs菌毛F165(1)主要和次要菌毛亚基编码基因的分析
Microb Pathog. 1994 Jan;16(1):15-25. doi: 10.1006/mpat.1994.1002.
4
Cloning of determinants encoding F165(2) fimbriae from porcine septicaemic Escherichia coli confirms their identity as F1C fimbriae.从猪败血性大肠杆菌中克隆编码F165(2)菌毛的决定簇，证实其为F1C菌毛。
Microbiology (Reading). 1995 Jan;141 ( Pt 1):221-8. doi: 10.1099/00221287-141-1-221.
5
Mutations in the uncE gene affecting assembly of the c-subunit of the adenosine triphosphatase of Escherichia coli.影响大肠杆菌三磷酸腺苷酶c亚基装配的uncE基因突变。
Biochem J. 1983 Jun 1;211(3):717-26. doi: 10.1042/bj2110717.
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Killing of an encapsulated strain of Escherichia coli by human serum.人血清对一种包膜化大肠杆菌菌株的杀伤作用。
Infect Immun. 1983 Jan;39(1):122-31. doi: 10.1128/iai.39.1.122-131.1983.
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A complementation analysis of the restriction and modification of DNA in Escherichia coli.大肠杆菌中DNA限制与修饰的互补分析。
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The relationship between the phosphate-binding protein and a regulator gene product from Escherichia coli.来自大肠杆菌的磷酸结合蛋白与一种调节基因产物之间的关系。
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9
Phosphate-specific transport system of Escherichia coli: nucleotide sequence and gene-polypeptide relationships.大肠杆菌的磷酸盐特异性转运系统：核苷酸序列及基因与多肽的关系
J Bacteriol. 1985 Jan;161(1):189-98. doi: 10.1128/jb.161.1.189-198.1985.
10
The physical map of the whole E. coli chromosome: application of a new strategy for rapid analysis and sorting of a large genomic library.完整大肠杆菌染色体的物理图谱：一种用于大型基因组文库快速分析和分类的新策略的应用
Cell. 1987 Jul 31;50(3):495-508. doi: 10.1016/0092-8674(87)90503-4.

鉴定pst-phoU操纵子中的一种突变，该突变可降低引起猪败血症的大肠杆菌菌株的致病性。

Identification of a mutation in the pst-phoU operon that reduces pathogenicity of an Escherichia coli strain causing septicemia in pigs.

作者信息

Daigle F, Fairbrother J M, Harel J

机构信息

Département de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada.

出版信息

Infect Immun. 1995 Dec;63(12):4924-7. doi: 10.1128/iai.63.12.4924-4927.1995.

DOI:10.1128/iai.63.12.4924-4927.1995
PMID:7591158
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC173707/
Abstract

We used transposon (TnphoA) mutagenesis to study the role of virulence factors of pathogenic Escherichia coli strains associated with septicemia in calves and piglets. We have produced an avirulent and serum-sensitive mutant of wild-type pathogenic strain 5131 O115:K"V165":F165 and have localized and identified the TnphoA insertion in the pstC gene of the pst-phoU operon. This operon encodes the PstSCAB transporter and PhoU protein that negatively regulate the phosphate (Pho) regulon. This mutation is pleiotropic and could have an effect on pathogenicity and on the production of the surface polysaccharides of strain 5131. The mutant demonstrated restored repressibility of alkaline phosphatase and regained the capacity to resist serum and to survive systemically for at least 5 days in experimentally inoculated pigs when complemented with plasmid pAN92, bearing the pst-phoU operon.

摘要

我们利用转座子（TnphoA）诱变技术来研究与犊牛和仔猪败血症相关的致病性大肠杆菌菌株毒力因子的作用。我们构建了野生型致病菌株5131 O115:K"V165":F165的无毒且血清敏感的突变体，并定位和鉴定了TnphoA插入到pst-phoU操纵子的pstC基因中。该操纵子编码PstSCAB转运蛋白和PhoU蛋白，它们对磷酸盐（Pho）调节子起负调控作用。这种突变具有多效性，可能会对5131菌株的致病性和表面多糖的产生产生影响。当用携带pst-phoU操纵子的质粒pAN92进行互补时，该突变体表现出碱性磷酸酶抑制作用的恢复，并重新获得了抵抗血清的能力，以及在实验接种的猪体内全身存活至少5天的能力。