Schürmann K, Vorwerk D, Kulisch A, Stroehmer-Kulisch E, Biesterfeld S, Stopinski T, Günther R W
Department of Diagnostic Radiology, University of Technology, Aachen, Germany.
Invest Radiol. 1995 Jul;30(7):412-20. doi: 10.1097/00004424-199507000-00004.
To compare technical aspects and neointima formation of a new Nitinol stent and a Wallstent.
A Nitinol sten and a Wallstent were placed into the iliac arteries of 14 sheep (total of 28 stents) and followed angiographically. Seven sheep were killed after 1 month and 7 after 4.5 months. Examination of histologic specimen by light microscopy was performed to determine neointimal and medial thickness inside the stents. Measurements were analyzed statistically.
Neointima was thicker in Nitinol stents (N) than in Wallstents (W) (P < 0.004), both adjacent to (W = 0.265 mm, N = 0.596 mm) and between the stent wires (W = 0.177 mm, N = 0.361 mm). Because of poor radiopacity and the Crochê releasing technique, delivery was more difficult with Nitinol stents. High-grade stenosis was found in two Nitinol stents at 1 and 4.5 months of follow-up, respectively. One Wallstent was insufficiently incorporated into the vessel wall.
The observed difference in neointima formation that may be caused by differences in design, mechanical properties or the metal alloy of the stents probably is too insignificant to be relevant to patency of large arteries. However, it may be relevant in small vessels such as coronary arteries.
比较一种新型镍钛诺支架与Wallstent支架的技术方面及新生内膜形成情况。
将一个镍钛诺支架和一个Wallstent支架置入14只绵羊的髂动脉（共28个支架），并进行血管造影随访。1个月后处死7只绵羊，4.5个月后处死另外7只。通过光学显微镜检查组织学标本，以确定支架内新生内膜和中膜的厚度。对测量结果进行统计学分析。
镍钛诺支架（N）的新生内膜比Wallstent支架（W）更厚（P < 0.004），在支架旁（W = 0.265毫米，N = 0.596毫米）以及支架丝之间（W = 0.177毫米，N = 0.361毫米）均如此。由于不透X线性差以及Crochê释放技术，镍钛诺支架的输送更困难。在随访的1个月和4.5个月时，分别在两个镍钛诺支架中发现了高度狭窄。一个Wallstent支架未充分融入血管壁。
观察到的新生内膜形成差异可能是由支架的设计、机械性能或金属合金差异所致，这可能对大动脉通畅性影响不大，但在诸如冠状动脉等小血管中可能具有相关性。
