Schürmann K, Vorwerk D, Kulisch A, Stroehmer-Kulisch E, Biesterfeld S, Stopinski T, Günther R W
Department of Diagnostic Radiology, University of Technology, Pauwelsstrasse 30, D-52057 Aachen, Germany.
Cardiovasc Intervent Radiol. 1996 Jul-Aug;19(4):248-54. doi: 10.1007/BF02577644.
To compare neointima formation following insertion of low-profile Nitinol stents, Palmaz stents, and Wallstents.
Nitinol stents, Palmaz stents, and Wallstents similar in size were transfemorally inserted into the iliac arteries of 12 sheep. Four stents per sheep were deployed; the position of the stents was varied so that each type of stent was placed in each position (right or left, proximal or distal) with equal frequency. Stent patency was followed by angiography. Six sheep were euthanized after 1 month, and the remaining six after 6 months. Iliac arteries were removed en bloc and prepared for histological examination. Neointimal and medial thickness were measured by light microscopy, and measurements were analyzed statistically.
Mean neointimal thickness both over (NO) and between (NB) the stent struts was greater in Wallstents (NO = 0.341 mm, NB = 0.368 mm) than in the Nitinol (NO = 0.260 mm, NB = 0.220 mm) and Palmaz stents (NO = 0.199 mm, NB = 0. 204 mm), but differences were not significant (p > 0.05). Medial atrophy in the area between the stent struts was greater in Wallstents compared with Nitinol and Palmaz stents (p < 0.007 and p < 0.02, respectively); in the area under the stent struts there was a significant difference only between Palmaz stents and Wallstents (p < 0.02).
Under defined experimental conditions, none of the three types of stent appears to be preferable to the others regarding neointima formation in the short- to mid-term follow-up period.
比较低轮廓镍钛合金支架、帕尔马兹支架和华尔支架植入后的新生内膜形成情况。
将尺寸相似的镍钛合金支架、帕尔马兹支架和华尔支架经股动脉植入12只绵羊的髂动脉。每只绵羊植入4个支架；改变支架位置，使每种类型的支架以相同频率置于每个位置（右侧或左侧、近端或远端）。通过血管造影术观察支架通畅情况。1个月后对6只绵羊实施安乐死，其余6只在6个月后实施安乐死。将髂动脉整块切除并准备进行组织学检查。通过光学显微镜测量新生内膜和中膜厚度，并对测量结果进行统计学分析。
华尔支架在支架支柱上方（NO）和支柱之间（NB）的平均新生内膜厚度（NO = 0.341毫米，NB = 0.368毫米）大于镍钛合金支架（NO = 0.260毫米，NB = 0.220毫米）和帕尔马兹支架（NO = 0.199毫米，NB = 0.204毫米），但差异不显著（p > 0.05）。与镍钛合金支架和帕尔马兹支架相比，华尔支架在支架支柱之间区域的中膜萎缩更严重（分别为p < 0.007和p < 0.02）；在支架支柱下方区域，仅帕尔马兹支架和华尔支架之间存在显著差异（p < 0.02）。
在特定实验条件下，在短期至中期随访期内，就新生内膜形成而言，这三种类型的支架均未显示出比其他支架更具优势。
