Bender W I
Spokane Headache Clinic, WA 99204, USA.
Headache. 1995 Sep;35(8):470-1. doi: 10.1111/j.1526-4610.1995.hed3508470.x.
Seventeen patients with migraine headaches, occurring at least twice a month, were successfully treated with an ACE inhibitor for prophylaxis. Most were given enalapril, some used lisinopril. Duration of treatment ranged from 3 months to 3 years. Side effects were generally not noted. Cough occurred in four patients. The mechanism of action is unknown. The lack of side effects and the presence of clearly sustained benefit in this small group of migraineurs should prompt further study and use of this class of drugs for prophylaxis.
17名每月至少发作两次偏头痛的患者通过使用一种血管紧张素转换酶（ACE）抑制剂进行预防性治疗获得成功。大多数患者使用依那普利，一些患者使用赖诺普利。治疗持续时间从3个月到3年不等。一般未观察到副作用。4名患者出现咳嗽。作用机制尚不清楚。在这一小群偏头痛患者中缺乏副作用且明显有持续疗效，这应该促使对这类药物进行进一步研究并用于预防性治疗。
