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含胶原蛋白的编织涤纶移植物的临床经验。

Clinical experience with a collagen impregnated woven Dacron graft.

作者信息

Tolan M, Wells F, Kendall S, Large S, Wallwork J

机构信息

Cardiothoracic Surgery Unit, Papworth Hospital, Cambridge, England.

出版信息

J Cardiovasc Surg (Torino). 1995 Aug;36(4):323-7.

PMID:7593141
Abstract

Vascular grafts continue to evolve. Recent developments have been aimed at decreasing porosity, increasing strength of prosthesis, increasing ease of handling and suturing and optimising flow characteristics. This study describes results with a recently developed collagen impregnated polyester prosthesis Hemashield Woven Double Velour, which does not require pre-clotting. Between January 1988 and December, 1991 such prostheses were used in 90 patients at Papworth Hospital. Fifty-eight, were used to replace the ascending aorta, 10 for the arch of the aorta and 28 for the descending aorta seven of whom were for coarctation and four for traumatic transections. In 60 cases the underlying disease was a dissected or ruptured aorta requiring emergency operation. There were 66 survivors with X-ray and CT follow-up of 6-52 months. Median blood loss was 630 ml range 380-1800 ml. There was no leakage from any of the grafts during surgery despite full perioperative heparinisation. For emergency/elective operations (N = 60/30) early mortality was 25%/10% (15/3) and late mortality 5%/6.6% (3/2). Of 15 patients who had interposition grafts for Type A dissection CT scans at 5-47 months showed one with chronic dissection proximal to the repair and 11 with persistent distal dissection. There was no evidence of late bleeding, seroma impaired healing or thickened neointima formation. It is concluded that there are no clinical disadvantages associated with collagen impregnation to set against the notable convenience of initial impermeability.

摘要

血管移植物不断发展。近期的进展旨在降低孔隙率、增强假体强度、提高操作和缝合的便利性以及优化血流特性。本研究描述了一种最近开发的胶原浸渍聚酯假体Hemashield Woven Double Velour的使用结果,该假体无需预凝血。1988年1月至1991年12月期间,帕普沃思医院的90例患者使用了此类假体。58例用于替换升主动脉,10例用于主动脉弓,28例用于降主动脉,其中7例用于主动脉缩窄,4例用于创伤性横断。60例患者的潜在疾病是主动脉夹层或破裂,需要急诊手术。66例患者存活,接受了6至52个月的X线和CT随访。中位失血量为630毫升,范围为380至1800毫升。尽管围手术期全程肝素化,但手术期间所有移植物均无渗漏。急诊/择期手术(n = 60/30)的早期死亡率为25%/10%(15/3),晚期死亡率为5%/6.6%(3/2)。在15例因A型夹层进行间置移植物手术的患者中,5至47个月的CT扫描显示,1例在修复近端有慢性夹层,11例有持续性远端夹层。没有晚期出血、血清肿、愈合受损或新生内膜增厚形成的证据。结论是,与胶原浸渍相关的临床缺点无法抵消初始不渗透性带来的显著便利性。

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