Comp P C, Jacocks R M, Taylor F B
J Lab Clin Med. 1979 Jan;93(1):120-7.
A dilute whole blood clot lysis assay was used to identify patients with a high incidence of DVT. Of 191 orthopedic and urologic patients who underwent surgery, the over-all incidence of DVT as determined by 125I-fibrinogen leg scan was 35% in the 92 individuals with abnormal assays and 1% in the 99 patients with normal assays. The likelihood that an individual patient might have developed DVT increased progressively with the number of abnormal assays (p less than 0.001). The incidence of DVT increased from 28% in patients who had one abnormal assay, to 35% in patients with two abnormal assays, to 56% in patients with three abnormal assays. These studies establish the clot lysis assay as a simple means to screen for patients with a high incidence of DVT. A normal assay can eliminate patients from consideration for more extensive studies (venography, fibrinogen scan, impedance plethysmography), whereas those patients with one or more abnormal assays should be seriously considered for these additional studies.
采用稀释全血凝块溶解试验来识别深静脉血栓形成（DVT）发生率高的患者。在191例接受手术的骨科和泌尿外科患者中，通过125I-纤维蛋白原腿部扫描确定的DVT总体发生率在92例试验异常的个体中为35%，在99例试验正常的患者中为1%。个体患者发生DVT的可能性随着异常试验数量的增加而逐渐增加（p<0.001）。DVT的发生率从有一次异常试验的患者中的28%，增加到有两次异常试验的患者中的35%，再增加到有三次异常试验的患者中的56%。这些研究确立了凝块溶解试验作为筛查DVT发生率高的患者的一种简单方法。正常的试验结果可将患者排除在更广泛检查（静脉造影、纤维蛋白原扫描、阻抗体积描记法）的考虑范围之外，而那些有一次或多次异常试验结果的患者应认真考虑进行这些额外检查。
