Bifulco G, Bruno I, Minale L, Riccio R, Calignano A, Debitus C
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.
J Nat Prod. 1994 Sep;57(9):1294-9. doi: 10.1021/np50111a020.
Two new diastereomeric brominated tris-indole alkaloids occurring as enantiomeric pairs, (+/-)-gelliusines A [1] and B [2], have been isolated from a deep water New Caledonian sponge (Gellius or Orina sp.), whose crude extract exhibited cytotoxicity against KB cells. Their structures were elucidated by spectroscopic methods including one- and two-dimensional nmr spectroscopy. The major compound, (+/-) gelliusine A [1], which showed very weak cytotoxicity, proved to be active at the serotonin receptor.
从一种新喀里多尼亚深水海绵（Gellius或Orina属）中分离出了两种新的非对映体溴化三吲哚生物碱，它们以对映体对的形式存在，即（±）-盖利辛A [1]和B [2]，该海绵的粗提物对KB细胞表现出细胞毒性。通过包括一维和二维核磁共振光谱在内的光谱方法阐明了它们的结构。主要化合物（±）盖利辛A [1]显示出非常弱的细胞毒性，但被证明对血清素受体有活性。
