el Hag A I, Karrar Z A
Department of Paediatrics & Child Health, University of Khartoum, Sudan.
Ann Trop Paediatr. 1995;15(1):69-76. doi: 10.1080/02724936.1995.11747751.
Nutritional vitamin D deficiency rickets was established in 41 Sudanese children aged from 3 months to 7 years by clinical, radiological and therapeutic response supported by biochemical investigations. There were 25 boys and 16 girls, of whom 42% were infants of less than 1 year. Forty-seven per cent of rachitic children were underweight. Six infants had early rickets with no bony swellings but had other clinical features and radiological evidence of rickets. One of them, aged 3 months, presented with hypocalcaemic convulsions. Three children had icthyosis. Serum alkaline phosphatase was raised in 75%, hypophosphataemia occurred in 68% and hypocalcaemia in 54% of patients. Anaemia, mostly hypochromic, was detected in 79%. Possible causes were poor socio-economic background, inadequate dietary intake in both mothers and children, prolonged breastfeeding, prematurity, limited sun exposure and type of residence. Nutritional vitamin D deficiency rickets should be looked for in Sudanese children, especially in preterms and in those living in flats.
通过临床、放射学检查以及生化检测支持下的治疗反应，确诊了41名年龄在3个月至7岁的苏丹儿童患有营养性维生素D缺乏佝偻病。其中有25名男孩和16名女孩，42%为1岁以下的婴儿。47%的佝偻病患儿体重不足。6名婴儿患有早期佝偻病，无骨骼肿胀，但有其他佝偻病的临床特征和放射学证据。其中一名3个月大的婴儿出现了低钙惊厥。3名儿童患有鱼鳞病。75%的患者血清碱性磷酸酶升高，68%的患者出现低磷血症，54%的患者出现低钙血症。79%的患者检测出贫血，多数为低色素性贫血。可能的原因包括社会经济背景差、母婴饮食摄入不足、母乳喂养时间过长、早产、日照有限以及居住类型。苏丹儿童，尤其是早产儿和居住在公寓中的儿童，应警惕营养性维生素D缺乏佝偻病。
