Fyer A J, Mannuzza S, Chapman T F, Martin L Y, Klein D F
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Arch Gen Psychiatry. 1995 Jul;52(7):564-73. doi: 10.1001/archpsyc.1995.03950190046007.
To investigate whether each of three DSM-III-R phobic disorders (simple phobia, social phobia, and agoraphobia with panic attacks) is familial and "breeds true."
Rates of each phobic disorder were contrasted in first-degree relatives of four proband groups: simple phobia, social phobia, agoraphobia with panic attacks, and not ill controls. Phobia probands were patients who had one of the phobia diagnoses but no other lifetime anxiety comorbidity.
We found moderate (two- to fourfold increased risk) but specific familial aggregation of each of the three DSM-III-R phobic disorders.
These results support a specific familial contribution to each of the three phobia types. However, conclusions are limited to cases occurring without lifetime anxiety comorbidity and do not imply homogeneity within categories.
调查三种《精神疾病诊断与统计手册第三版修订版》（DSM-III-R）中的恐惧症（单纯恐惧症、社交恐惧症和伴有惊恐发作的广场恐惧症）是否具有家族性且“真实遗传”。
对比了四组先证者的一级亲属中每种恐惧症的发病率：单纯恐惧症、社交恐惧症、伴有惊恐发作的广场恐惧症以及非患病对照。恐惧症先证者是指患有上述恐惧症诊断之一但无其他终生焦虑共病的患者。
我们发现三种DSM-III-R恐惧症中的每一种都有中度（风险增加两到四倍）但特定的家族聚集性。
这些结果支持家族因素对三种恐惧症类型中的每一种都有特定影响。然而，结论仅限于无终生焦虑共病的病例，并不意味着类别内部的同质性。
