Folkers K, Simonsen R
Institute for Biomedical Research, University of Texas at Austin 78705, USA.
Biochim Biophys Acta. 1995 May 24;1271(1):281-6. doi: 10.1016/0925-4439(95)00040-b.
Coenzyme Q10 (vitamin Q10) is biosynthesized in the human body and is functional in bioenergetics, anti-oxidation reactions, and in growth control, etc. It is indispensable to health and survival. The first double-blind trial was with twelve patients, ranging from 7-69 years of age, having diseases including the Duchenne, Becker, and the limb-girdle dystrophies, myotonic dystrophy. Charcot-Marie-Tooth disease, and the Welander disease. The control coenzyme Q10 (CoQ10) blood level was low and ranged from 0.5-0.84 microgram/ml. They were treated for three months with 100 mg daily of CoQ10 and a matching placebo. The second double-blind trial was similar with fifteen patients having the same categories of disease. Since cardiac disease is established to be associated with these muscle diseases, cardiac function was blindly monitored, and not one mistake was made in assigning CoQ10 and placebo to the patients in both trials. Definitely improved physical performance was recorded. In retrospect, a dosage of 100 mg was too low although effective and safe. Patients suffering from these muscle dystrophies and the like, should be treated with vitamin Q10 indefinitely.
辅酶Q10（维生素Q10）在人体内生物合成，在生物能量学、抗氧化反应以及生长控制等方面发挥作用。它对健康和生存至关重要。首次双盲试验有12名患者，年龄在7至69岁之间，患有杜氏肌营养不良症、贝克肌营养不良症、肢带型肌营养不良症、强直性肌营养不良症、夏科 - 马里 - 图斯病和韦兰德病等疾病。对照组辅酶Q10（CoQ10）的血液水平较低，范围为0.5至0.84微克/毫升。他们每天服用100毫克CoQ10和匹配的安慰剂进行为期三个月的治疗。第二次双盲试验类似，有15名患有相同类别疾病的患者。由于已确定心脏病与这些肌肉疾病有关，因此对心脏功能进行了盲法监测，并且在两项试验中给患者分配CoQ10和安慰剂时没有出现一次错误。记录到身体机能明显改善。回顾来看，100毫克的剂量虽然有效且安全，但过低了。患有这些肌肉营养不良症等疾病的患者，应无限期地用维生素Q10进行治疗。
