Eidt S, Stolte M
Institute of Pathology, University of Cologne, Germany.
Eur J Gastroenterol Hepatol. 1995 Apr;7(4):318-21.
The evidence linking Helicobacter pylori and non-cardia gastric adenocarcinoma is accumulating. Patterns of strain specificities and host factors that increase epithelial proliferation and have implications for mutagenic effects are evolving. The decision by the World Health Organization and the International Agency for Research on Cancer to classify H. pylori as a 'definite' carcinogen, however, represents a milestone in the association of H. pylori with gastric carcinogenesis. The importance of H. pylori in gastric lymphoma has been underscored by the finding that H. pylori eradication can induce complete regression in low-grade mucosa-associated lymphoid tissue lymphomas, at least in the early stages of development.
幽门螺杆菌与非贲门胃腺癌之间的关联证据越来越多。菌株特异性模式以及增加上皮增殖并具有诱变作用的宿主因素正在不断演变。然而，世界卫生组织和国际癌症研究机构将幽门螺杆菌列为“明确”致癌物的决定，代表了幽门螺杆菌与胃癌发生关联方面的一个里程碑。幽门螺杆菌根除可使低度黏膜相关淋巴组织淋巴瘤完全消退，至少在疾病发展的早期阶段如此，这一发现凸显了幽门螺杆菌在胃淋巴瘤中的重要性。
