Andersson S O, Baron J, Wolk A, Lindgren C, Bergström R, Adami H O
Department of Urology, Orebro Medical Center, Sweden.
Cancer Epidemiol Biomarkers Prev. 1995 Apr-May;4(3):187-92.
We undertook a population-based case-control study to investigate early life risk factors for prostate cancer. Information on dietary habits during childhood and adolescence, childhood environment, pubertal development, and physical activity was collected by face-to-face interviews with 256 (74.6%) of all eligible cases and 252 (76.6%) of all selected controls, frequency matched by age. All potential controls were screened for prostate cancer with negative findings. Odds ratios with 95% confidence intervals were estimated by logistic regression. Analyses of localized (T0-2' M0) and more advanced cancers were made separately. In general, there was no clear association between diet and prostate cancer risk. An increased risk associated with childhood living in more densely populated, compared with rural, areas was found (odds ratio = 2.1; 95% confidence interval = 1.3-3.5); this effect was most apparent for localized cancers (odds ratio = 3.2' 95% confidence interval = 1.7-6.2). There was no substantial association between adult height or body mass index and prostate cancer, but exercise appeared negatively associated with risk (P value for trend, 0.13). We conclude that our study provides some indications that exposures early in life are important in the etiology of prostate cancer.
我们开展了一项基于人群的病例对照研究，以调查前列腺癌的早期生活危险因素。通过对所有符合条件的256例病例（占74.6%）和所有选定对照中的252例（占76.6%）进行面对面访谈，收集了童年和青少年时期的饮食习惯、童年环境、青春期发育及身体活动方面的信息，并按年龄进行频率匹配。所有潜在对照均接受了前列腺癌筛查，结果为阴性。通过逻辑回归估计比值比及95%置信区间。分别对局限性（T0 - 2' M0）癌和更晚期癌症进行分析。总体而言，饮食与前列腺癌风险之间无明显关联。发现童年生活在人口密集地区而非农村地区会增加患病风险（比值比 = 2.1；95%置信区间 = 1.3 - 3.5）；这种影响在局限性癌症中最为明显（比值比 = 3.2；95%置信区间 = 1.7 - 6.2）。成人身高或体重指数与前列腺癌之间无显著关联，但运动似乎与风险呈负相关（趋势P值为0.13）。我们得出结论，我们的研究提供了一些迹象表明生命早期的暴露在前列腺癌病因学中很重要。
