Zhang L, Kokkonen G, Roth G S
Molecular Physiology and Genetics Section, NIA, Francis Scott Key Medical Center, NIH, Baltimore, MD 21224, USA.
Brain Res. 1995 Apr 17;677(1):177-9. doi: 10.1016/0006-8993(95)00197-x.
Apoptotic neurons have been identified in normal adult rat striatum by terminal deoxynucleotidyl transferase mediated dUTP-biotin nick end labeling technique. This observation suggests that neuronal programmed cell death starts at an early stage of adult life and may contribute to the aging associated neuronal loss. In addition, the frequency of apoptotic cells was found to significantly increase in old rats, which implies that aging itself accelerates the process.
通过末端脱氧核苷酸转移酶介导的dUTP-生物素缺口末端标记技术，已在正常成年大鼠纹状体中鉴定出凋亡神经元。这一观察结果表明，神经元程序性细胞死亡在成年生活的早期阶段就已开始，并且可能导致与衰老相关的神经元丢失。此外，发现老年大鼠中凋亡细胞的频率显著增加，这意味着衰老本身加速了这一过程。
