Aizawa H, Niimura M
Department of Dermatology, Jikei University School of Medicine, Tokyo, Japan.
J Dermatol. 1995 Apr;22(4):249-52. doi: 10.1111/j.1346-8138.1995.tb03381.x.
The purpose of this study was to measure the serum levels of IGF-1 in women with postadolescent acne compared to normal controls, and evaluate the relationship of these levels to the levels of androgens, in order to investigate the possible role of IGF-1 in the pathogenesis of acne. Eighty-two female patients with acne between 20 and 25 years of age and thirty-one age-matched control women were studied. We measured the serum levels of total testosterone (T), free testosterone (FT), dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEA-S), and insulin-like growth factor-1 (IGF-1). The levels of IGF-1 in patients with acne (1.26 +/- 0.52 U/ml) were significantly (p < 0.001) increased over those of controls (0.96 +/- 0.32 U/ml). Of 82 acne patients, six (7%) had IGF-1 levels which exceeded the normal range, but there were no significant correlations between IGF-1 and T, FT, DHT or DHEA-S levels or between IGF-1 and acne severity. Since the measurement of serum IGF-1 levels is a convenient indicator of GH secretion, the increase of serum IGF-1 levels seen in some acne patients might reflect an increase of GH.
本研究的目的是测量青春期后痤疮女性与正常对照组相比的血清胰岛素样生长因子-1（IGF-1）水平，并评估这些水平与雄激素水平的关系，以研究IGF-1在痤疮发病机制中的可能作用。对82名年龄在20至25岁之间的痤疮女性患者和31名年龄匹配的对照女性进行了研究。我们测量了血清总睾酮（T）、游离睾酮（FT）、二氢睾酮（DHT）、硫酸脱氢表雄酮（DHEA-S）和胰岛素样生长因子-1（IGF-1）的水平。痤疮患者的IGF-1水平（1.26±0.52 U/ml）显著高于对照组（0.96±0.32 U/ml）（p<0.001）。在82名痤疮患者中，6名（7%）的IGF-1水平超过正常范围，但IGF-1与T、FT、DHT或DHEA-S水平之间以及IGF-1与痤疮严重程度之间均无显著相关性。由于血清IGF-1水平的测量是生长激素（GH）分泌的一个便捷指标，一些痤疮患者血清IGF-1水平的升高可能反映了GH的增加。
