Starkstein S E, Migliorelli R, Tesón A, Petracca G, Chemerinsky E, Manes F, Leiguarda R
Department of Neuropsychiatry and Behavioural Neurology, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina.
J Neurol Neurosurg Psychiatry. 1995 Jul;59(1):55-60. doi: 10.1136/jnnp.59.1.55.
This study examined the prevalence and correlates of pathological affect in Alzheimer's disease. A consecutive series of 103 patients with Alzheimer's disease were examined with a comprehensive psychiatric assessment that included the pathological laughing and crying scale (PLACS). Forty patients (39%) showed pathological affect: 25% showed crying episodes, and 14% showed laughing or mixed (laughing and crying) episodes. Patients with pathological affect crying showed significantly higher depression scores and a significantly higher frequency of major depression and dysthymia than patients with no pathological affect. Patients with mixed pathological affect showed significantly more subcortical atrophy on CT than patients with pathological affect crying. Forty seven per cent of the patients with pathological affect had no congruent mood disorder, and they showed a significantly longer duration of illness and more severe anosognosia than patients with pathological affect that was congruent with an underlying mood disorder. The study validates the PLACS, and shows the high prevalence of pathological affect in Alzheimer's disease.
本研究调查了阿尔茨海默病中病理性情感的患病率及其相关因素。对连续的103例阿尔茨海默病患者进行了全面的精神评估，其中包括病理性哭笑量表（PLACS）。40例患者（39%）表现出病理性情感：25%出现哭泣发作，14%出现大笑或混合（哭笑）发作。与无病理性情感的患者相比，有病理性情感哭泣的患者抑郁评分显著更高，重度抑郁和心境恶劣的发生率也显著更高。与有病理性情感哭泣的患者相比，有混合病理性情感的患者CT显示皮层下萎缩更明显。47%有病理性情感的患者没有相符的心境障碍，与伴有相符心境障碍的病理性情感患者相比，他们的病程显著更长，失认症更严重。该研究验证了PLACS，并显示了阿尔茨海默病中病理性情感的高患病率。
