Ofili E O, Kern M J, St Vrain J A, Donohue T J, Bach R, al-Joundi B, Aguirre F V, Castello R, Labovitz A J
Department of Internal Medicine, St. Louis University Health Sciences Center, Mo., USA.
Am Heart J. 1995 Jul;130(1):37-46. doi: 10.1016/0002-8703(95)90233-3.
To characterize coronary blood flow velocity parameters and to determine the relation among velocity, volumetric flow, and vascular resistance in awake human beings, we performed paired proximal and distal velocity measurements in 28 angiographically normal coronary arteries. Mean velocity, peak velocity, diastolic-to-systolic velocity ratio, and diameter and cross-sectional area of proximal and distal arteries were determined and coronary flow and vascular resistance computed. Mean velocity and coronary vasodilator reserve were similar for all three native arteries and were preserved from proximal to distal segments. Volumetric flow decreased from proximal to distal segments. The demonstrated inverse and curvilinear (polynomial) relation between volumetric flow and vascular resistance agrees with theoretical and animal models of coronary physiologic characteristics and suggests a nadir of coronary vascular resistance below which coronary flow no longer increases.
为了描述清醒人类冠状动脉血流速度参数，并确定速度、容积流量和血管阻力之间的关系，我们对28条血管造影正常的冠状动脉进行了近端和远端速度的配对测量。测定了平均速度、峰值速度、舒张期与收缩期速度比值以及近端和远端动脉的直径和横截面积，并计算了冠状动脉血流和血管阻力。所有三支天然动脉的平均速度和冠状动脉血管扩张储备相似，且从近端到远端节段均得以保留。容积流量从近端到远端节段逐渐降低。所显示的容积流量与血管阻力之间的反比和曲线（多项式）关系与冠状动脉生理特征的理论和动物模型一致，并提示冠状动脉血管阻力存在一个最低点，低于该点冠状动脉血流不再增加。
