多发性硬化症患者家庭成员中的淋巴细胞毒性抗体。

Lymphocytotoxic antibodies in family members of patients with multiple sclerosis.

作者信息

Schocket A L, Weiner H L

出版信息

Lancet. 1978 Mar 18;1(8064):571-3. doi: 10.1016/s0140-6736(78)91023-1.

Abstract

Cold-reactive lymphocytotoxic antibodies were found in sera from 14 of 21 (67%) patients with multiple sclerosis. A significantly (p less than 0.01) greater frequency of these antibodies was also demonstrated in patients' household members (12 of 18 [67%]) compared to siblings living elsewhere (3 of 14 [21%]) or normal controls (1 of 13 [8%]). No difference in antibody frequency was found between consanguineous and non-consanguineous family members. These findings suggest that the increase frequency of lymphocytotoxic antibodies in these multiple-sclerosis patients and their family members is an indicator of the presence of a transmissible agent, probably a virus, in many patients with multiple sclerosis.

摘要

在21例多发性硬化症患者中，有14例（67%）的血清中发现了冷反应性淋巴细胞毒性抗体。与居住在其他地方的兄弟姐妹（14例中有3例[21%]）或正常对照组（13例中有1例[8%]）相比，这些抗体在患者家庭成员中出现的频率也显著更高（18例中有12例[67%]，p<0.01）。在有血缘关系和无血缘关系的家庭成员之间，未发现抗体频率存在差异。这些发现表明，这些多发性硬化症患者及其家庭成员中淋巴细胞毒性抗体频率的增加，是许多多发性硬化症患者体内存在一种可传播因子（可能是一种病毒）的指标。