福氏志贺菌在柯萨奇B1病毒感染的HEp-2细胞中的黏附和增殖
Shigella flexneri adherence to and multiplication in coxsackie B1 virus-infected HEp-2 cells.
作者信息
Modalsli K R, Bukholm G, Holberg-Petersen M, Degré M
机构信息
Kaptein W. Wilhelmsen og Frues Bakteriologiske Institutt, University of Oslo, Rikshospitalet, Norway.
出版信息
APMIS. 1995 Apr;103(4):254-60. doi: 10.1111/j.1699-0463.1995.tb01103.x.
Coxsackie B1 virus infection enhances the susceptibility of in vitro cultured HEp-2 cells to invasiveness by Shigella flexneri. We have studied the effect of viral infection on two phases of the invasiveness. Only a minor part was mediated by enhanced bacterial adherence to the cells, and the intracellular multiplication was unaffected by the virus. Enhanced adherence was not dependent on the presence of the gene product of the 140 Md virulence associated plasmid. Our data indicate that enhanced invasiveness induced by viral infection is mediated by an effect on other phases of the invasiveness.
柯萨奇B1病毒感染增强了体外培养的HEp-2细胞对福氏志贺菌侵袭的易感性。我们研究了病毒感染对侵袭两个阶段的影响。只有一小部分是由细菌对细胞的粘附增强介导的，并且细胞内增殖不受病毒影响。粘附增强不依赖于140 Md毒力相关质粒基因产物的存在。我们的数据表明，病毒感染诱导的侵袭性增强是由对侵袭其他阶段的影响介导的。
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