Tang G, Blanco M C, Fox J G, Russell R M
Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
J Nutr. 1995 Jul;125(7):1945-51. doi: 10.1093/jn/125.7.1945.
To study the effects of canthaxanthin supplementation on the tissue distribution of canthaxanthin, other carotenoids, vitamin A and vitamin E, 26 spayed female ferrets (2 mo of age) were used. Ferrets were assigned to receive a commercial ferret diet and a gavage of canthaxanthin [50 mg/(kg body wt.d)] or a gavage of placebo beadlets (0 mg canthaxanthin) 5 d/wk. Serum canthaxanthin concentrations in the canthaxanthin-fed group increased from 0 at baseline to 37.76 +/- 5.34 nmol/L trans and 77.10 +/- 12.60 nmol/L cis canthaxanthin at 12 mo. Further accumulation of canthaxanthin did not occur with continuous dosing. After 2 y of receiving canthaxanthin beadlets by gavage, the ferrets did not show a detectable concentration of canthaxanthin in the eyes, nor did they have clinical signs of toxicity. Canthaxanthin concentrations were highest in liver, with high concentrations also seen in fat, lung and small intestine. The sum of alpha and beta-carotene concentrations detected in livers was significantly higher in the canthaxanthin-fed group than in the placebo-fed group, but not significantly higher when individual carotenes were compared. However, alpha-tocopherol concentrations in the livers and lungs and lutein/zeaxanthin in the fats of the ferrets fed canthaxanthin were significantly lower than in those fed the placebo. Retinoid concentrations in tissues of the ferrets fed canthaxanthin were not different from those of the placebo-fed group. The effects of canthaxanthin supplementation on other antioxidants and vitamin A nutrients demonstrate either a synergistic or antagonistic relationship, depending on the specific tissue assayed.
为研究补充角黄素对其在组织中的分布以及其他类胡萝卜素、维生素A和维生素E的影响，使用了26只2月龄的雌性去势雪貂。雪貂被分为两组，一组接受市售雪貂饲料并每周5天灌胃角黄素[50毫克/（千克体重·天）]，另一组接受安慰剂小丸（0毫克角黄素）灌胃。角黄素喂养组的血清角黄素浓度从基线时的0增加到12个月时反式角黄素为37.76±5.34纳摩尔/升、顺式角黄素为77.10±12.60纳摩尔/升。持续给药后角黄素未进一步蓄积。经2年灌胃角黄素小丸后，雪貂眼中未检测到角黄素浓度，也没有毒性的临床体征。角黄素浓度在肝脏中最高，在脂肪、肺和小肠中也有较高浓度。角黄素喂养组肝脏中检测到的α-胡萝卜素和β-胡萝卜素浓度之和显著高于安慰剂喂养组，但单独比较各胡萝卜素时差异不显著。然而，角黄素喂养的雪貂肝脏和肺中的α-生育酚浓度以及脂肪中的叶黄素/玉米黄质浓度显著低于安慰剂喂养组。角黄素喂养的雪貂组织中的视黄醇浓度与安慰剂喂养组无差异。补充角黄素对其他抗氧化剂和维生素A营养素的影响表明，根据所检测的特定组织，存在协同或拮抗关系。
