Bottone E J, Namdari H
Division of Infectious Diseases, Mount Sinai Hospital, New York, NY 10029-6574, USA.
Mt Sinai J Med. 1995 May;62(3):216-20.
Listeria monocytogenes is a facultative intracellular pathogen causing mainly meningitis and septicemia in immunocompromised hosts. From July 1988 through December 1989, 16 patients at The Mount Sinai Hospital were diagnosed as having listeriosis shortly after admission, 14 within a one-year period (July 1988-July 1989). Because this incidence was almost double the incidence in previous years (< 8 annually), an epidemiologic and microbiologic investigation was undertaken to determine a potential route of acquisition of L. monocytogenes. On the basis of plasmid profile, bacteriocin (enterocin) susceptibility pattern, and serotype, no single epidemic strain could be identified. Although direct evidence was lacking, we concluded that our patients may have acquired L. monocytogenes through transient contamination of food.
单核细胞增生李斯特菌是一种兼性细胞内病原体，主要在免疫功能低下的宿主中引起脑膜炎和败血症。从1988年7月到1989年12月，西奈山医院有16名患者在入院后不久被诊断为患有李斯特菌病，其中14例发生在一年期间（1988年7月至1989年7月）。由于这一发病率几乎是前几年发病率（每年<8例）的两倍，因此开展了一项流行病学和微生物学调查，以确定单核细胞增生李斯特菌的潜在感染途径。根据质粒图谱、细菌素（肠球菌素）敏感性模式和血清型，未发现单一的流行菌株。尽管缺乏直接证据，但我们得出结论，我们的患者可能通过食物的短暂污染感染了单核细胞增生李斯特菌。
