胰多肽对促胰液素刺激的胰腺分泌的抑制作用。
Inhibition of secretin stimulated pancreatic secretion by pancreatic polypeptide.
作者信息
Adrian T E, Besterman H S, Mallinson C N, Greenberg G R, Bloom S R
出版信息
Gut. 1979 Jan;20(1):37-40. doi: 10.1136/gut.20.1.37.
Abstract
The effect of PP on secretin-stimulated pancreatic secretion was assessed in five healthy subjects. During an intravenous infusion of BPP at a dose which produced plasma levels similar to those seen after meals in healthy young adults the volume and bicarbonate content of duodenal juice was reduced by 25% (p less than 0.05) and 24% (p less than 0.05) respectively, while protein and bilirubin concentrations were more markedly reduced by 68% (p less than 0.0005) and 67% (p less than 0.0005) respectively. PP, thus, may be an important inhibitory factor in the control of bilirubin and pancreatic enzyme secretion in man.
摘要
在五名健康受试者中评估了PP对促胰液素刺激的胰腺分泌的影响。在以产生与健康年轻成年人餐后所见血浆水平相似的剂量静脉输注BPP期间，十二指肠液的体积和碳酸氢盐含量分别降低了25%（p<0.05）和24%（p<0.05），而蛋白质和胆红素浓度分别更显著地降低了68%（p<0.0005）和67%（p<0.0005）。因此，PP可能是人体胆红素和胰腺酶分泌控制中的一个重要抑制因子。
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