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儿童结肠癌

Carcinoma of the colon in a child.

作者信息

Ko Y S, Lin L H, Chen D F

机构信息

Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan, R.O.C.

出版信息

Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1995 May-Jun;36(3):227-30.

PMID:7618477
Abstract

A 13-year-old boy presented with carcinoma of the ascending colon. He had had intermittent abdominal pain for about one year, with body weight loss, prior to admission. Physical examination showed diffuse abdominal tenderness, but no palpable mass. Lower GI barium study and colonofibroscopic examination showed a protruding mass over the proximal ascending colon. At operation, right hemicolectomy with ileotransversecolostomy was performed, the pathologic finding was adenocarcinoma, signet-ring cell type. Although chemotherapy with 5-fluorouracil, mitomycin, and levamisole were given subsequently, the patient expired one year after surgery because of multiple metastasis. Carcinoma of the colon is extremely rare in the young. Mucin-producing adenocarcinoma is the most predominant type of colon cancer, and most are of signet-ring cell carcinoma. While prognosis is relatively bright in adult, the prognosis is quite unfavorable in children because of the preponderance of the poor histological characteristics and the difficulty of diagnosis.

摘要

一名13岁男孩被诊断为升结肠癌。入院前,他间歇性腹痛约一年,伴有体重减轻。体格检查显示全腹弥漫性压痛,但未触及肿块。下消化道钡剂造影和结肠镜检查显示升结肠近端有一突出肿物。手术行右半结肠切除术加回肠横结肠造口术,病理结果为印戒细胞型腺癌。尽管随后给予了5-氟尿嘧啶、丝裂霉素和左旋咪唑化疗,但患者术后一年因多处转移死亡。结肠癌在年轻人中极为罕见。黏液腺癌是结肠癌最主要的类型,大多数为印戒细胞癌。虽然成人结肠癌的预后相对较好,但儿童患者由于组织学特征较差且诊断困难,预后相当不佳。

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