Roberts C J, Millar J M, Goat V A
Nuffield Department of Anaesthetics, John Radcliffe Hospital, Headington, Oxford.
Anaesthesia. 1995 Jun;50(6):559-62. doi: 10.1111/j.1365-2044.1995.tb06054.x.
This prospective, double-blind study examined the antiemetic effectiveness of the addition of droperidol to a morphine solution for use in patient-controlled analgesia in a group of 50 patients undergoing elective lumbar laminectomy. The addition of 20 mg droperidol to 120 mg morphine in 60 ml saline given by a Baxter 'Infusor' patient-controlled analgesia device reduced the incidence of vomiting as compared to the addition of sodium chloride from 42.8% to 12.5% (p = 0.028) and of nausea from 71.4% to 29.2% (p = 0.005). The proportion of patients requiring rescue antiemetic therapy was reduced from 47.6% to 16.7% (p = 0.025) and the time interval to the first use of rescue antiemetic agent was significantly prolonged (p = 0.029). The use of droperidol was associated with an increased degree of sedation during the first 12 h after operation.
这项前瞻性双盲研究在50例接受择期腰椎椎板切除术的患者中，考察了在吗啡溶液中添加氟哌利多用于患者自控镇痛的止吐效果。通过百特公司的“输注泵”患者自控镇痛装置，在60毫升生理盐水中加入20毫克氟哌利多和120毫克吗啡，与加入氯化钠相比，呕吐发生率从42.8%降至12.5%（p = 0.028），恶心发生率从71.4%降至29.2%（p = 0.005）。需要抢救性止吐治疗的患者比例从47.6%降至16.7%（p = 0.025），首次使用抢救性止吐药的时间间隔显著延长（p = 0.029）。使用氟哌利多与术后头12小时内镇静程度增加有关。
