川崎病中半胱氨酰白三烯生成增加。
Increased generation of cysteinyl leukotrienes in Kawasaki disease.
作者信息
Mayatepek E, Lehmann W D
机构信息
Department of General Paediatrics, University Children's Hospital, Heidelberg, Germany.
出版信息
Arch Dis Child. 1995 Jun;72(6):526-7. doi: 10.1136/adc.72.6.526.
Endogenous cysteinyl leukotriene synthesis was assessed in 10 patients with Kawasaki disease and 10 healthy controls by measuring excretion of leukotriene E4 (LTE4) in urine. LTE4 was increased more than fivefold in patients with Kawasaki disease compared with controls (median (range) 55.3 (31.8-120.6) v 10.2 (7.1-14.9) nmol/mol creatinine); this suggests that cysteinyl leukotrienes are involved in the pathophysiology of Kawasaki disease. Leukotriene synthetase inhibition or receptor antagonism may therefore offer a new potential therapeutic approach in children with this disease.
通过测量尿中白三烯E4（LTE4）的排泄量，对10例川崎病患儿和10名健康对照者的内源性半胱氨酰白三烯合成情况进行了评估。与对照组相比，川崎病患儿的LTE4增加了五倍多（中位数（范围）55.3（31.8 - 120.6）对10.2（7.1 - 14.9）nmol/mol肌酐）；这表明半胱氨酰白三烯参与了川崎病的病理生理过程。因此，对白三烯合成酶的抑制或对白三烯受体的拮抗作用可能为患有这种疾病的儿童提供一种新的潜在治疗方法。
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