Carson H J, Tojo D P, Chow J M, Hammadeh R, Raslan W F
Department of Pathology, Loyola University Medical Center, Maywood, Chicago, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jun;79(6):738-46. doi: 10.1016/s1079-2104(05)80309-9.
Carcinosarcomas are rare neoplasms that exhibit heterologous malignant epithelial and stromal components. We report two cases of salivary gland carcinosarcoma with immunohistochemical analysis and clinical follow-up that provide insights into the pathogenesis and behavior of these tumors. In one case, a 51-year-old black woman had a 15-year history of a hard, asymptomatic, infraauricular mass that recently had undergone rapid growth. The tumor showed adenocarcinoma and osteosarcoma. She died 9 months after diagnosis. In another case, a 78-year-old white woman had a large soft palate mass that had been present for several years and had recently caused dysphagia. The tumor showed adenocarcinoma and leiomyosarcoma. The patient is alive at 9 months follow-up. Although malignant epithelial and stromal components characterize carcinosarcomas, immunohistochemical studies suggest that both elements are derived from a common precursor cell, possibly of myoepithelial origin. These cases support this concept and perhaps suggest a spectrum of differentiation that this precursor cell may exhibit.
癌肉瘤是一种罕见的肿瘤，具有异源性恶性上皮和间质成分。我们报告两例涎腺癌肉瘤病例，并进行免疫组化分析和临床随访，以深入了解这些肿瘤的发病机制和行为。其中一例，一名51岁的黑人女性有一个15年病史的坚硬、无症状的耳下肿块，该肿块最近生长迅速。肿瘤表现为腺癌和骨肉瘤。她在诊断后9个月死亡。另一例，一名78岁的白人女性有一个存在数年的大软腭肿块，最近导致吞咽困难。肿瘤表现为腺癌和平滑肌肉瘤。在9个月的随访中，该患者仍存活。尽管恶性上皮和间质成分是癌肉瘤的特征，但免疫组化研究表明这两种成分均源自一个共同的前体细胞，可能起源于肌上皮。这些病例支持这一概念，并且可能提示了这种前体细胞可能表现出的一系列分化。
